Di-t-butyl N,N-diethylphosphoramidite
di-tert-butyl N,N-diethylphosphor-amidite
CAS: 117924-33-1
Molecular Formula: C12H28NO2P
Di-t-butyl N,N-diethylphosphoramidite - Names and Identifiers
Di-t-butyl N,N-diethylphosphoramidite - Physico-chemical Properties
| Molecular Formula | C12H28NO2P |
| Molar Mass | 249.33 |
| Density | 0.896 g/mL at 25 °C (lit.) |
| Boling Point | 39-41 °C/0.3 mmHg (lit.) |
| Flash Point | 173°F |
| Water Solubility | Hydrolyzes in water. Soluble in chloroform and methanol. |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| Vapor Presure | 0.104mmHg at 25°C |
| Appearance | Oil |
| Color | Clear Colourless |
| BRN | 4175262 |
| pKa | 4.41±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Moisture Sensitive |
| Sensitive | Moisture Sensitive |
| Refractive Index | n20/D 1.434(lit.) |
Di-t-butyl N,N-diethylphosphoramidite - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 4.4-10-21 |
| HS Code | 29319090 |
Di-t-butyl N,N-diethylphosphoramidite - Introduction
Di-tert-butyl N,N-diethylaminophosphite (also known as DEET) is an organic compound. Its chemical formula is C12H17NO2P. The following is a description of its nature, use, preparation and safety information:
Nature:
DEET is a colorless liquid with a low melting point and melting point. It is soluble in most organic solvents, such as ethers, ketones and esters, and is compatible with many plastic materials. It has a strong special smell.
Use:
DEET is a compound widely used as a mosquito repellent. It can effectively prevent all kinds of insect bites, especially mosquitoes and ticks. Because of its good repellent effect on insects, DEET is widely used in outdoor activities and in areas where infectious diseases such as malaria and dengue fever are prevalent.
Preparation Method:
DEET is usually prepared by reacting phosphorous anhydride (POCl3) with diethylamine. First, diethylamine was added dropwise to the reflux apparatus, and then phosphite anhydride was added gradually. After completion of the reaction, DEET can be precipitated from the reaction solution upon cooling to room temperature, and a pure product can be obtained by filtration.
Safety Information:
DEET is safe for humans under general conditions of use and is widely used worldwide. However, at high concentrations and prolonged exposure, DEET may cause some discomfort such as skin irritation and allergic reactions. When using DEET, we recommend that you follow the following safety precautions:
1. avoid contact with eyes and oral mucosa.
2. Do not overuse, especially when using it on children, follow the instructions for use.
3. Do not apply DEET directly to wounds or damaged skin.
4. Wash hands thoroughly after use and avoid applying DEET to hands that come into contact with food.
5. people who use DEET for a long time should check their skin condition regularly, and stop using it immediately if they are not suitable.
Nature:
DEET is a colorless liquid with a low melting point and melting point. It is soluble in most organic solvents, such as ethers, ketones and esters, and is compatible with many plastic materials. It has a strong special smell.
Use:
DEET is a compound widely used as a mosquito repellent. It can effectively prevent all kinds of insect bites, especially mosquitoes and ticks. Because of its good repellent effect on insects, DEET is widely used in outdoor activities and in areas where infectious diseases such as malaria and dengue fever are prevalent.
Preparation Method:
DEET is usually prepared by reacting phosphorous anhydride (POCl3) with diethylamine. First, diethylamine was added dropwise to the reflux apparatus, and then phosphite anhydride was added gradually. After completion of the reaction, DEET can be precipitated from the reaction solution upon cooling to room temperature, and a pure product can be obtained by filtration.
Safety Information:
DEET is safe for humans under general conditions of use and is widely used worldwide. However, at high concentrations and prolonged exposure, DEET may cause some discomfort such as skin irritation and allergic reactions. When using DEET, we recommend that you follow the following safety precautions:
1. avoid contact with eyes and oral mucosa.
2. Do not overuse, especially when using it on children, follow the instructions for use.
3. Do not apply DEET directly to wounds or damaged skin.
4. Wash hands thoroughly after use and avoid applying DEET to hands that come into contact with food.
5. people who use DEET for a long time should check their skin condition regularly, and stop using it immediately if they are not suitable.
Last Update：2024-04-09 21:04:16
